James J. Connolly won the inaugural event in 1926.
We caught up with the 38-year-old shortly after his indoor season opener.
He wants to go for sub-3:50.
He will square off against Lawi Lalang in the 2-mile race.
He's going for his best-ever 2-mile time.
It was his first race on the roads.
The 22-year-old will run the Fifth Avenue Mile on Sunday.
Defending champions Bernard Lagat and Jenny Simpson return.
Dejen Gebremeskel of Ethiopia is the pre-race favorite.
Can Team USA win more medals than it did in 2008?