The Americans bring a strong field to this year's race in the heart of Manhattan.
At least nine runners have broken Roger Bannister's famous barrier.
They join the American defending champions.
Craig Miller and Heather Kampf hope to repeat their victories.
Craig Miller prevailed in the men's race.
Craig Miller and heather Kampf took home national titles!
Both athletes won $4000 in prize money.
Ryan Hall is entered with just 24 days of recovery since this Boston Marathon.
Lukas Verzbicas was a close second.