Timothy Ritchie and Neely Spence Gracey are the pre-race favorites.
Delilah DiCrescenzo was the first woman to cross the line.
The 33rd annual race takes place at midnight on New Year's Eve.
Over 5000 runners took part in the race's 33rd edition.
She's a world indoor silver medalist.
Carmen Douma-Hussar, Sarah Porter, Landon Peacock, and Christian Hesch set to race under a glittering sky of fireworks at midnight.
The annual event was inspired by Sao Paulo's New Year's Eve run.
A lot is going on despite the traditional break between seasons.
Last month's winner of the Emerald Nut's Midnight Run said she came to the race for the competition.