The American won the race down one of New York's most famous streets in 2011 and 2013.
The American is seeking her third victory at the annual dash in New York City.
The 18-year-old won the world junior 3000m title in July.
The 23-year-old took fourth at the Fifth Avenue Mile.
Here's a look at how the elite runners did in the annual dash down one of New York City's famous streets.
Nick Willis was well under 4 minutes for the men.
The American miler, her coach, and training partners abandoning their English training base.
The Americans bring a strong field to this year's race in the heart of Manhattan.
It was his first race on the roads.