The 25-year old took over 13 minutes off her 26.2-mile personal best at last weekend's ASICS L.A. Marathon.
American Lauren Kleppin, who trains with the Mammoth Track Club, was third in a personal-best 2:28:48.
A February race date and national TV broadcast helped secure the winning bid.
The troubled actress has been working with Shannon Rowbury on her running since leaving rehab last month.
Now a Masters athlete, Kastor finishes third in the elite field in Los Angeles.
27-year-old's time of 2:26:08 breaks the Belarusian national record.
Deena's husband to oversee the LA Roadrunners Training Program.
Fatuma Sado won the 27th annual L.A. Marathon in the women's category on Sunday, posting a time of 2 hours, 25 minutes and 39 seconds.
Race-day temperatures are expected to be chilly, too.