Sambu clocks 22:01 en route to victory, setting an 8K world record.
The 29-year-old broke the American record with a time of 31:37.
The race around Central Park will take place June 14.
Past champions will attempt to make history at the annual women’s-only race in Albany, New York.
Thousands turned out in Boston for the first road race since that city's marathon.
Ethiopian takes the title nearly a minute ahead of her closest competitor.
She is looking to dip under 2:20.
The Ethiopian was awarded $10,000 for her victories.
Peter Kirui prevailed in the men's division.