The race adjacent to Central Park featured fast times and photo finishes.
Prague Half Marathon winner Joyce Chepkirui headlines the inaugural women's field.
The 41-year-old Kastor won last year's event in 1:13:25, and was victorious at the Rock 'n' Roll Dallas Half two weeks ago.
The program benefits both NYRR members and non-members.
A portion of West 228th Street will become "Ted Corbitt Way."
All net proceeds will be donated to the victims of Hurricane Sandy.
Runner turnout in the Big Apple continues to rise.
His first NYRR running class started in 1978.
He recently turned pro last November.