Shalane Flanagan finishes second, Sean Quigley places seventh to finish as top Americans.
Christo Landry won the men's USA title in 46:41.
Michael Nicks prevailed in the men's race.
She's a three-time Olympic Trials finalist and will debut in the half marathon there.
The steeplechaser is aiming for a spot on the U.S. Olympic team.
2010 world indoor champion Bernard Lagat leads men's squad.
A late-race surge paid off for her.